Dominant optic atrophy: Culprit mitochondria in the optic nerve.
Abstract
Dominant optic atrophy (DOA) is an inherited mitochondrial disease leading to specific degeneration of retinal ganglion cells (RGCs), thus compromising transmission of visual information from the retina to the brain. Usually, DOA starts during childhood and evolves to poor vision or legal blindness, affecting the central vision, whilst sparing the peripheral visual field. In 20% of cases, DOA presents as syndromic disorder, with secondary...
Paper Details
Title
Dominant optic atrophy: Culprit mitochondria in the optic nerve.
Published Date
Jul 1, 2021
Volume
83
Pages
100935
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