The nuclear DICER–circular RNA complex drives the deregulation of the glioblastoma cell microRNAome
Abstract
The assortment of cellular microRNAs ("microRNAome") is a vital readout of cellular homeostasis, but the mechanisms that regulate the microRNAome are poorly understood. The microRNAome of glioblastoma is substantially down-regulated in comparison to the normal brain. Here, we find malfunction of the posttranscriptional maturation of the glioblastoma microRNAome and link it to aberrant nuclear localization of DICER, the major enzymatic complex...
Paper Details
Title
The nuclear DICER–circular RNA complex drives the deregulation of the glioblastoma cell microRNAome
Published Date
Dec 18, 2020
Journal
Volume
6
Issue
51
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