Inhibiting cough by silencing large pore-expressing airway sensory neurons with a charged sodium channel blocker

Published: Dec 7, 2020
Abstract
null Although multiple diseases of the respiratory system cause cough, there are few effective treatments for this common condition. We previously developed a strategy to treat pain and itch via the long-lasting inhibition of nociceptor sensory neurons with QX-314, a cationic sodium channel blocker that selectively enters only into activated nociceptors by permeating through the endogenous TRPV1 and TRPA1 large pore ion channels they express. In...
Paper Details
Title
Inhibiting cough by silencing large pore-expressing airway sensory neurons with a charged sodium channel blocker
Published Date
Dec 7, 2020
Journal
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