[18F]-Fluciclovine PET discrimination of recurrent intracranial metastatic disease from radiation necrosis

Background Stereotactic radiosurgery (SRS) is often the primary treatment modality for patients with intracranial metastatic disease. Despite advances in magnetic resonance imaging, including use of perfusion and diffusion sequences and molecular imaging, distinguishing radiation necrosis from progressive tumor remains a diagnostic and clinical challenge. We investigated the sensitivity and specificity of 18 F-fluciclovine PET to accurately...