Cortical thickness and mean diffusivity AD signatures at average age 56 predict 12‐year progression to mild cognitive impairment

Background Alzheimer’s disease (AD) brain signatures based on cortical thickness, with or without hippocampal volume, predict progression from mild cognitive impairment (MCI) to AD. It would be advantageous if AD signatures could predict earlier progression to MCI. Toward that end, a signature sensitive to microstructural changes that may predate macrostructural atrophy should be useful. We hypothesized that: 1) AD signatures in cognitively...