Lower MRI‐indexed locus coeruleus integrity in autosomal‐dominant Alzheimer's disease

Background Tau pathology, a hallmark of Alzheimer’s disease, accumulates early in life in the locus coeruleus, the primary source of cortical norepinephrine. Dysfunctions in the noradrenergic system are hypothesized to contribute to Alzheimer’s progression; however, in‐vivo evidence has been impeded by methodological challenges in non‐invasive assessments. Advances in high‐resolution brainstem magnetic resonance imaging (MRI) hold potential to...