Metastatic salivary gland carcinoma: A role for stereotactic body radiation therapy? A study of AIRO-Head and Neck working group.

Published on Dec 15, 2020in Oral Diseases2.613
· DOI :10.1111/ODI.13755
Ciro Franzese19
Estimated H-index: 19
(Humanitas University),
Rossana Ingargiola2
Estimated H-index: 2
+ 13 AuthorsEster Orlandi22
Estimated H-index: 22
Objectives The role of radiotherapy (RT) for oligometastases is currently established in different oncological settings but data on salivary gland cancer (SGC) are lacking. We evaluated the role of RT in oligometastatic SGC patients, focusing on stereotactic body radiation therapy (SBRT). Materials and methods We performed a retrospective, multicentric study of oligometastatic SGC treated with palliative RT or SBRT. Endpoints included response evaluation and local control (LC). Results Between 2006 and 2016, 64 patients were collected from 9 Italian Cancer Centers, on behalf of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Head and Neck Working Group. 37 patients (57.8%) were suffering from adenoid cystic carcinoma (ACC) and 27 patients (42.2%) had non-ACC. Thirty-four patients underwent palliative RT (53,1%), and 30 received SBRT (46,9%). Most common metastatic sites were bone for palliative RT and lung for SBRT. Among patients treated with SBRT, an objective response or a stability was observed in all treated lesions. After a median follow-up of 29.2 months (range 2.3-117.1), LC at 12 months was 57.5% for patients treated with SBRT and was higher in ACC subgroup. Conclusion We confirmed the potential role of SBRT in the management of oligometastatic SGC patients to control limited burden of disease considering the absence of effective systemic therapies.
#1Stefano CavalieriH-Index: 8
#2Luigi MarianiH-Index: 50
Last. Laura D. LocatiH-Index: 31
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Abstract Background Distant metastases in adenoid cystic carcinoma (ACC) are common. There is no consensus on the management of metastatic disease because no therapeutic approach has demonstrated improvement in overall survival (OS) and because of prolonged life expectancy. The aim of this study is to build and validate a prognostic nomogram for metastatic ACC patients. Methods The study end-point was OS, measured from the date of first metastatic presentation to death/last follow-up. A retrospe...
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#1David A. Palma (London Health Sciences Centre)H-Index: 57
#2Robert OlsonH-Index: 45
Last. Suresh Senan (VU: VU University Amsterdam)H-Index: 87
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#1Bhumsuk Keam (Seoul National University Hospital)H-Index: 45
#2Eun Joo Kang (KU: Korea University)H-Index: 11
Last. Sung-Bae Kim (UOU: University of Ulsan)H-Index: 57
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#1Aman Sharma (IGMC: Indira Gandhi Medical College)H-Index: 30
#1Aman Sharma (IGMC: Indira Gandhi Medical College)H-Index: 2
Last. Joost J. Nuyttens (EUR: Erasmus University Rotterdam)H-Index: 29
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#1Matthias Guckenberger (UZH: University of Zurich)H-Index: 69
#2Yolande Lievens (Ghent University Hospital)H-Index: 22
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Summary Oligometastatic disease has been proposed as an intermediate state between localised and systemically metastasised disease. In the absence of randomised phase 3 trials, early clinical studies show improved survival when radical local therapy is added to standard systemic therapy for oligometastatic disease. However, since no biomarker for the identification of patients with true oligometastatic disease is clinically available, the diagnosis of oligometastatic disease is based solely on i...
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#2Denise Bernhardt (University Hospital Heidelberg)H-Index: 14
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#1Jungirl Seok (Seoul National University Hospital)H-Index: 4
#2Doh Young Lee (SNU: Seoul National University)H-Index: 14
Last. Soon Hyun Ahn (Seoul National University Hospital)H-Index: 15
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#1Pierluigi Bonomo (UniFI: University of Florence)H-Index: 20
#2Daniela Greto (UniFI: University of Florence)H-Index: 18
Last. Lorenzo Livi (UniFI: University of Florence)H-Index: 29
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#1David A. Palma (London Health Sciences Centre)H-Index: 57
#2Robert OlsonH-Index: 45
Last. Suresh Senan (VU: VU University Amsterdam)H-Index: 87
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Summary Background The oligometastatic paradigm suggests that some patients with a limited number of metastases might be cured if all lesions are eradicated. Evidence from randomised controlled trials to support this paradigm is scarce. We aimed to assess the effect of stereotactic ablative radiotherapy (SABR) on survival, oncological outcomes, toxicity, and quality of life in patients with a controlled primary tumour and one to five oligometastatic lesions. Methods This randomised, open-label p...
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#1Davide FranceschiniH-Index: 19
#2Fiorenza De RoseH-Index: 15
Last. Marta Scorsetti (Humanitas University)H-Index: 41
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Purpose This study evaluated patients, treatment, or disease characteristics that could predict response to stereotactic body radiation therapy (SBRT) and survival in a database of patients with oligometastatic disease from different solid tumors. Methods and Materials Patients treated with SBRT for oligometastatic disease between 2014 and 2015 were included. Patients were defined as oligometastatic if they were affected by a maximum of 5 active lesions in 3 different sites. They had to be treat...
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Cited By1
#1Daijiro KobayashiH-Index: 7
#2Takanori Abe (Saitama Medical University)H-Index: 9
Last. Tatsuya Ohno (Gunma University)H-Index: 28
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Background Adenoid cystic carcinoma (ACC) is a rare malignant tumor involving mostly the head and neck region, and frequently the salivary glands. The development of lung metastasis after treatment of the primary tumor is a common occurrence in ACC. Although lung metastases show a slow rate of growth, approximately 10% of patients die from distant metastases. The radioresistance of ACC limits the efficacy of conventional radiotherapy for lung metastases, and the optimal dose remains to be determ...