The Potential of Proteolytic Chimeras as Pharmacological Tools and Therapeutic Agents

Volume: 25, Issue: 24, Pages: 5956 - 5956
Published: Dec 16, 2020
Abstract
The induction of protein degradation in a highly selective and efficient way by means of druggable molecules is known as targeted protein degradation (TPD). TPD emerged in the literature as a revolutionary idea: a heterobifunctional chimera with the capacity of creating an interaction between a protein of interest (POI) and a E3 ubiquitin ligase will induce a process of events in the POI, including ubiquitination, targeting to the proteasome,...
Paper Details
Title
The Potential of Proteolytic Chimeras as Pharmacological Tools and Therapeutic Agents
Published Date
Dec 16, 2020
Journal
Volume
25
Issue
24
Pages
5956 - 5956
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