Surface modification of titanium implants by silk fibroin/Ag co-functionalized strontium titanate nanotubes for inhibition of bacterial-associated infection and enhancement of in vivo osseointegration

Surface modification of surgical grade titanium implants to promote bone cell integration and prevent infection is an urgent problem in orthopedic surgery. The synergistic effect of silk fibroin (SF) and strontium (Sr) has the dual functions of promoting bone formation and inhibiting osteoclasts, and silver (Ag) has excellent antibacterial activity. Therefore, this research uses technologies such as anodizing, hydrothermal synthesis, and layered...