A novel miRNA inhibits metastasis of prostate cancer via decreasing CREBBP-mediated histone acetylation

To identify novel miRNAs implicated in prostate cancer metastasis. Sixty-five prostate cancer tissues and paired pan-cancer tissues were sequenced. Novel miRNAs were re-analyzed by MIREAP program. Biological functions of miR-N5 were transwell experiment and colony formation. Target genes of miR-N5 were analyzed by bioinformatic analysis. Downstream of target gene was analyzed by The Cancer Genome Atlas (TCGA) and Memorial Sloan Kettering Cancer...