Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine.

Published on Feb 1, 2021in Annals of Oncology32.976
· DOI :10.1016/J.ANNONC.2020.11.013
Raffaella Casolino2
Estimated H-index: 2
(Glas.: University of Glasgow),
Chiara Braconi29
Estimated H-index: 29
(Glas.: University of Glasgow)
+ 8 AuthorsTalia Golan23
Estimated H-index: 23
(Sheba Medical Center)
This review summarises the recent evidence on preoperative therapeutic strategies in pancreatic cancer and discusses the rationale for an imminent need for a personalized therapeutic approach in non-metastatic disease. The molecular diversity of pancreatic cancer and its influence on prognosis and treatment response, combined with the failure of "all-comer" treatments to significantly impact on patient outcomes, requires a paradigm shift towards a genomic-driven approach. This is particularly important in the preoperative, potentially curable setting, where a personalized treatment allocation has the substantial potential to reduce pancreatic cancer mortality.
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