Epigenetics

Immune system

Mass cytometry

Population

Biology

Gene

Cell biology

Demography

Granzyme B

Flow cytometry

Phenotype

Sociology

Cytotoxic T cell

In vitro

Immunology

Genetics

Immunity

Aging affects the immune system and establishes a chronic low-grade inflammation (inflammaging). Mogilenko et al. defined organ-specific and common alterations of immune cell populations in aging and identified a distinct subset of clonal GZMK+ CD8+ T cells as a conserved cellular hallmark of inflammaging in mice and humans.

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging