Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats
Abstract
Expansions of CAG/CTG trinucleotide repeats in DNA are the cause of at least 17 degenerative human disorders, including Huntington’s Disease. Repeat instability is thought to occur via the formation of intrastrand hairpins during replication, repair, recombination, and transcription though relatively little is known about their structure and dynamics. We use single-molecule Förster resonance energy transfer to study DNA three-way junctions...
Paper Details
Title
Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats
Published Date
Jan 8, 2021
Journal
Volume
12
Issue
1
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