Inhibition of miR-122 reduced atherosclerotic lesion formation by regulating NPAS3-mediated endothelial to mesenchymal transition

Volume: 265, Pages: 118816 - 118816
Published: Jan 1, 2021
Abstract
Endothelial to mesenchymal transition (EndMT) is closely related to atherosclerosis. Herein, we aim to determine whether miR-122 is involved in EndMT and the underlying mechanism in atherosclerosis. qRT-PCR was performed to detect miR-122 expression in ApoE−/− mice and cellular EndMT model induced by H2O2. MiR-122 expression in vivo was modulated by lenti-virus injection and by genetic manipulation. Hematoxylin and eosin (HE) and Oil-red O...
Paper Details
Title
Inhibition of miR-122 reduced atherosclerotic lesion formation by regulating NPAS3-mediated endothelial to mesenchymal transition
Published Date
Jan 1, 2021
Volume
265
Pages
118816 - 118816
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