In Vivo Analysis of mtDNA Replication at the Single Molecule Level and with High Resolution.
Abstract
Single molecule analysis of replicating DNA (SMARD) is a powerful methodology that allows in vivo analysis of replicating DNA; identification of origins of replication, assessment of fork directionality, and measurement of replication fork speed. SMARD, which has been extensively used to study replication of nuclear DNA, involves incorporation of thymidine analogs to nascent DNA chains and their subsequent visualization through immune detection....
Paper Details
Title
In Vivo Analysis of mtDNA Replication at the Single Molecule Level and with High Resolution.
Published Date
Jan 1, 2021
Journal
Volume
2192
Pages
21 - 34
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