Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease
Abstract
In Alzheimer's disease (AD), the Braak staging scheme suggests a stereotypical tau spreading pattern that does, however, not capture interindividual variability in tau deposition. This complicates the prediction of tau spreading, which may become critical for defining individualized tau-PET readouts in clinical trials. Since tau is assumed to spread throughout connected regions, we used functional connectivity to improve tau spreading...
Paper Details
Title
Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease
Published Date
Nov 27, 2020
Journal
Volume
6
Issue
48
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