Clinicopathological and Molecular Characteristics of Pleomorphic Invasive Lobular Carcinoma
Abstract
Pleomorphic invasive lobular carcinoma (PILC) is a distinct morphological and biologically aggressive variant of invasive lobular carcinoma (ILC). We hypothesized that was due to de novo activation of PI3K/Akt/mTOR pathway in PILC resulting in higher proliferation rate and markers of cell cycle activation. We identified PILC and ILC tumors and tested for PI3K/Akt/mTOR pathway activation by immunohistochemistry (PTEN and pS6K1) and gene...
Paper Details
Title
Clinicopathological and Molecular Characteristics of Pleomorphic Invasive Lobular Carcinoma
Published Date
Nov 22, 2020
Volume
2020
Pages
1 - 7
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