IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis
Abstract
IFN regulatory factor 3 (IRF3) is a transcription factor that is activated by multiple pattern-recognition receptors. We demonstrated previously that IRF3 plays a detrimental role in a severe mouse model of sepsis, induced by cecal ligation and puncture. In this study, we found that IRF3-knockout (KO) mice were greatly protected from sepsis in a clinically relevant version of the cecal ligation and puncture model incorporating crystalloid fluids...
Paper Details
Title
IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis
Published Date
Jan 15, 2021
Journal
Volume
206
Issue
2
Pages
398 - 409
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