Microbial Glycosylation of Phenanthrene and Bibenzyls by Mucor hiemalis

Published on Nov 24, 2020in Natural Product Communications0.986
· DOI :10.1177/1934578X20974508
Bomi Nam6
Estimated H-index: 6
(Chonnam National University),
Ah-Reum Han7
Estimated H-index: 7
,
Ik-Soo Lee30
Estimated H-index: 30
(Chonnam National University)
Sources
Abstract
Microbial transformation of denthyrsinin (1), gigantol (2), and batatasin III (3), the major constituents of Dendrobium species (Orchidaceae), was performed using the filamentous fungus Mucor hiema...
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#1Di Zhou (SPU: Shenyang Pharmaceutical University)H-Index: 10
#2Wenhui Chang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Ning Li (SPU: Shenyang Pharmaceutical University)H-Index: 30
view all 8 authors...
Abstract Neuroinflammation are involved in the pathogenesis of many neurodegenerative disorders. In our screening of natural effective neuroinflammatory inhibitors from natural products, stilbenes, such as resveratrol and its analogues, have received considerable attention over the last several decades as anti-neuroinflammatory agents. Then, Bletilla striata attracted our attention due to its abundant stilbenes portion, PE fraction. So, three new stilbenes: dusuanlansin E1 (23a), dusuanlansin E2...
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#1Bomi NamH-Index: 6
#2Seung Mok Ryu (KU: Korea University)H-Index: 10
Last. Ah-Reum HanH-Index: 7
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Two new phenanthrenes, (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one (1) and 2,7-dihydroxy-phenanthrene-1,4-dione (2), were isolated from the ethyl acetate-soluble fraction of Dendrobii Herba, together with seven known phenanthrenes (3–9), two bibenzyls (10–12), and a lignan (13). Structures of 1 and 2 were elucidated by analyzing one-dimensional (1D) and two-dimensional (2D)-NMR and High-resolution electrospray ionization mass spectra (HR-ESI-MS) data. The absolute configura...
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#1Salinee Na Ranong (Chula: Chulalongkorn University)H-Index: 1
#2Kittisak Likhitwitayawuid (Chula: Chulalongkorn University)H-Index: 29
Last. Boonchoo Sritularak (Chula: Chulalongkorn University)H-Index: 23
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AbstractTwo new dihydrophenanthrenes, dendroinfundin A (1) and dendroinfundin B (2) were isolated from the whole plant of Dendrobium infundibulum, together with 7 known compounds (3–9). The structures of the new compounds (1 and 2) were established on the basis of their spectroscopic data. All of the isolates were evaluated for their α-glucosidase and pancreatic lipase inhibitory activities. Batatasin III (5) and dendrosinen B (9) showed strong α-glucosidase inhibitory activity. Dendrosinen B (9...
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#1Shao-Wei Han (Peking Union Medical College)H-Index: 6
#2Chao Wang (Peking Union Medical College)H-Index: 21
Last. Shuai Li (Peking Union Medical College)H-Index: 22
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Abstract Ten previously undescribed glucosyloxybenzyl succinate derivatives, pleionosides A-J, and fifteen known compounds were isolated from the pseudobulbs of Pleione bulbocodioides (Franch.) Rolfe. Their structures were elucidated by a combination of MS and NMR data, physical and chemical methods and a comparison with known compounds. Furthermore, three compounds exhibited potent hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in in vitro assays, with...
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#2Huiling Liu (CAS: Chinese Academy of Sciences)H-Index: 9
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Abstract Flavonoid glycosides are widespread in plants, acting as phytoalexin against biotic stress. They also have great health benefits to human body. Some of them have been used as medicines and nutraceuticals due to good bioactivities and low toxicities. Glycosylation affords structural complexity and diversity of flavonoids. It further modifies the bioactivity and bioavailability in vivo. In this article, the up-to-date development on flavonoid glycosides and their bioactivities are reviewe...
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#1Virunh Kongkatitham (Chula: Chulalongkorn University)H-Index: 3
#2Chawanphat Muangnoi (Chula: Chulalongkorn University)H-Index: 10
Last. Boonchoo Sritularak (Chula: Chulalongkorn University)H-Index: 23
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Abstract Oxidative stress and inflammatory responses are the main causes of various diseases and disorders. To prevent these incidents, antioxidant and anti-inflammatory agents are needed. Dendrobium parishii, known in Thai as “Ueang Khrang Sai San” was studied for chemical constituents by solvent extraction, followed by column chromatography. Seven compounds including two new (1–2) and five known compounds (3–7) were isolated and screened for antioxidant activity using DPPH, ORAC and deoxyribos...
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#2Nareerat Petpiroon (Chula: Chulalongkorn University)H-Index: 4
Last. Pithi Chanvorachote (Chula: Chulalongkorn University)H-Index: 30
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Lung cancer is the leading cause of cancer-related deaths worldwide. Compound Batatasin III isolated from Dendrobium draconis Rchb.f. was tested for the possible anti-cancer activities including anti-proliferative, anti-migration and invasion in human non-small lung cancer H460 cells.The effect of Batatasin III on viability and proliferation of H460 cells was investigated by the 3-[4,5-dimethylthiazol-2-yl]-2,5diphenyl tetrazoliumbromide (MTT) assay. Migration and invasion assays were performed....
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#1Feng-Qing Xu (Anhui University of Chinese Medicine)H-Index: 15
#2Weiwei Fan (CAS: Chinese Academy of Sciences)H-Index: 10
Last. Jiang-Miao Hu (CAS: Chinese Academy of Sciences)H-Index: 21
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AbstractFour new glucosides, named as gigantol-5-O-β-d-glucopyranoside (1), 9,10-dihydro-aphyllone A-5-O-β-d-glucopyranoside (2), ficusal-4-O-β-d-glucopyranoside (3), botrydiol-15-O-β-d-glucopyranoside (4), together with eight known compounds (5–12) were isolated from the n-BuOH extract of the stems of Dendrobium fimbriatum Hook. Their structures were elucidated by the analyses of spectroscopic data.
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#1Prapapan Temkitthawon (NU: Naresuan University)H-Index: 7
#2Kanokwan Changwichit (NU: Naresuan University)H-Index: 6
Last. Kornkanok Ingkaninan (NU: Naresuan University)H-Index: 32
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: Phosphodiesterase 5 (PDE5) inhibitors can be used for the treatment of erectile dysfunction and pulmonary hypertension. In order to search for new leads of PDE5 inhibitors, we investigated the chemical constituents of the tubers of Eulophia macrobulbon (E.C. Parish & Rchb. f.) Hook. f. A new phenanthrene, 9,10-dihydro-4-(4'-hydroxybenzyl)-2,5-dimethoxyphenanthrene-1,7-dio (1) and three known phenanthrenes i.e., 1-(4'-hydroxybenzyl)-4,8- dimethoxyphenanthrene-2,7-diol (2), (9,10-dihydro-2,5-dim...
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#1Zengyang Yu (SHU: Shanghai University)H-Index: 8
#2Tianyu Zhang (SHU: Shanghai University)H-Index: 9
Last. Zhengtao Wang (SHU: Shanghai University)H-Index: 61
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Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway
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Cited By1
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#1Jia-Duo Yu (Kunming Medical University)H-Index: 1
#2Ya-Ping Chen (Kunming Medical University)H-Index: 2
Last. Yu-Peng Li (Kunming Medical University)H-Index: 3
view all 6 authors...
Abstract Phytochemical investigation of Bulbophyllum wendlandianum (Kraenzl.) Dammer led to the isolation of twenty-three compounds 1–23 (flavanthrinin 1, coelonin 2, lusianthridin 3, densiflorol B 4, plicatol B 5, batatasin-lll 6, gigantol 7, 5-hydroxy-3,3′-dimethoxy-2-(p-hydroxybenzyl) bibenzyl 8, 2,2-dimethyl-5-hydroxy-6-carboxy-7-(2-phenylethyl) 9, tristin 10, p-hydroxybenzyl ethyl ether 11, p-hydroxybenzaldehyde 12, hydroquinone 13, coniferaldehyde 14, p-hydroxybenzyl alcohol 15, 3,4-dihydr...
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