OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†
Abstract
Although reactive oxygen species (ROS) are required for spermatogonial stem cell (SSC) self-renewal, they induce DNA damage and are harmful to SSCs. However, little is known about how SSCs protect their genome during self-renewal. Here, we report that Ogg1 is essential for SSC protection against ROS. While cultured SSCs exhibited homologous recombination-based DNA double-strand break repair at levels comparable with those in pluripotent stem...
Paper Details
Title
OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†
Published Date
Nov 30, 2020
Journal
Volume
104
Issue
3
Pages
706 - 716
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