Contrasting haemodynamic effects of exercise and saline infusion in older adults with pulmonary arterial hypertension

The contemporary population of patients with pulmonary arterial hypertension (PAH) are older, with high prevalence of cardiovascular risk factors [1], and potentially at risk for left ventricular diastolic dysfunction [2]. Accordingly, the effect of exercise or volume expansion may elicit augmented increases in pulmonary artery wedge pressure (PAWP) [3, 4], in addition to abnormal behavior of pulmonary artery (PA) pressures. Footnotes This...