Mice lacking global Stap1 expression do not manifest hypercholesterolemia
Abstract
Background Autosomal dominant familial hypercholesterolemia (ADH; MIM#143890) is one of the most common monogenic disorders characterized by elevated circulatory LDL cholesterol. Initial studies in humans with ADH identified a potential relationship with variants of the gene encoding signal transducing adaptor family member protein 1 (STAP1; MIM#604298). However, subsequent studies have been contradictory. In this study, mice lacking global...
Paper Details
Title
Mice lacking global Stap1 expression do not manifest hypercholesterolemia
Published Date
Nov 23, 2020
Journal
Volume
21
Issue
1
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