A novel danshensu/tetramethypyrazine derivative attenuates oxidative stress‑induced autophagy injury via the AMPK‑mTOR‑Ulk1 signaling pathway in cardiomyocytes

Myocardial ischemia/reperfusion injury (MIRI) is an inevitable and unsolved clinical problem in the treatment of ischemic heart diseases. Compound DT‑010 is a novel danshensu/tetramethylpyrazine derivative and was examined as a candidate for treating MIRI. In the present study, MTT, lactate dehydrogenase assay and Hoechst staining data indicated that DT‑010 attenuated tert‑butylhydroperoxide (t‑BHP)‑induced oxidative damage by increasing cell...