Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo

Volume: 80, Issue: 4, Pages: 475 - 486
Published: Dec 2, 2020
Abstract
Antitumour necrosis factor (TNF) therapy has revolutionised treatment of several chronic inflammatory diseases, including spondyloarthritis (SpA). However, TNF inhibitors (TNFi) are not effective in all patients and the biological basis for treatment failure remains unknown. We have analysed induced immune responses to define the mechanism of action of TNF blockers in SpA and to identify immunological correlates of responsiveness to TNFi.Immune...
Paper Details
Title
Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo
Published Date
Dec 2, 2020
Volume
80
Issue
4
Pages
475 - 486
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