Role of the lncRNA BACE1-AS in shared disease mechanisms between heart failure and Alzheimer's disease
Abstract
Background BACE1 encodes for β-secretase, the key enzyme involved in β-amyloid (βA) generation, a peptide well known for its involvement in Alzheimer's disease (AD). Of note, heart failure (HF) and AD share several risk factors and effectors. We recently showed that, in the heart of ischemic HF patients, the levels of both BACE1, its antisense RNA BACE1-AS and βA are all increased. BACE1-AS positively regulates the expression of BACE1,...
Paper Details
Title
Role of the lncRNA BACE1-AS in shared disease mechanisms between heart failure and Alzheimer's disease
Published Date
Nov 1, 2020
Journal
Volume
41
Issue
Supplement_2
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