Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene
Abstract
Existing animal models of cystic fibrosis (CF) have provided key insights into CF pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or high maintenance costs. Here, we report the CRISPR/Cas9-mediated generation of CF rabbits, a model with a relatively long lifespan and affordable maintenance and care costs. CF rabbits supplemented solely with oral osmotic laxative had a median survival of approximately 40 days...
Paper Details
Title
Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene
Published Date
Jan 11, 2021
Journal
Volume
6
Issue
1
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