An insight into the interaction between α-ketoamide- based inhibitor and coronavirus main protease: A detailed in silico study
Abstract
The search for therapeutic drugs that can neutralize the effects of COVID-2019 (SARS-CoV-2) infection is the main focus of current research. The coronavirus main protease (Mpro) is an attractive target for anti-coronavirus drug design. Further, α-ketoamide is proved to be very effective as a reversible covalent-inhibitor against cysteine proteases. Herein, we report on the non-covalent to the covalent adduct formation mechanism of...
Paper Details
Title
An insight into the interaction between α-ketoamide- based inhibitor and coronavirus main protease: A detailed in silico study
Published Date
Feb 1, 2021
Journal
Volume
269
Pages
106510 - 106510
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