Circulating B Cells, Plasma Cells, and Treg Associate with ANCA Levels in ANCA-associated Vasculitis

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a group of debilitating autoimmune diseases characterized by uncontrolled inflammation and endothelial injury that often associates with pauci-immune necrotizing and crescentic glomerulonephritis. Despite the improved therapeutic options, both mortality and development of end-stage kidney disease remain high among AAV patients.1Jennette J.C. Nachman P.H. ANCA...