NKCC1, an Elusive Molecular Target in Brain Development: Making Sense of the Existing Data

Cells6.00
Volume: 9, Issue: 12, Pages: 2607 - 2607
Published: Dec 4, 2020
Abstract
Ionotropic GABA transmission is mediated by anion (mainly Cl−)-permeable GABAA receptors (GABAARs). In immature neurons, GABA exerts depolarizing and sometimes functionally excitatory actions, based on active uptake of Cl− by the Na-K-2Cl cotransporter NKCC1. While functional evidence firmly shows NKCC1-mediated ion transport in immature and diseased neurons, molecular detection of NKCC1 in the brain has turned out to be extremely difficult. In...
Paper Details
Title
NKCC1, an Elusive Molecular Target in Brain Development: Making Sense of the Existing Data
Published Date
Dec 4, 2020
Journal
Volume
9
Issue
12
Pages
2607 - 2607
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