Breast cancer radiation therapy – Authors' reply

Birgitte Offersen and Jens Overgaard argue that 26 Gy in five fractions is biologically inferior to 40 Gy in 15 fractions on the basis of α/β point estimates; however, therapeutic ratio is better defined clinically. In the FAST-Forward trial,1Brunt AM Haviland JS Wheatley DA et al.Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre,...