Plasmon-enhanced stimulated Raman scattering microscopy with single-molecule detection sensitivity
Abstract
Stimulated Raman scattering (SRS) microscopy allows for high-speed label-free chemical imaging of biomedical systems. The imaging sensitivity of SRS microscopy is limited to ~10 mM for endogenous biomolecules. Electronic pre-resonant SRS allows detection of sub-micromolar chromophores. However, label-free SRS detection of single biomolecules having extremely small Raman cross-sections (~10−30 cm2 sr−1) remains unreachable. Here, we demonstrate...
Paper Details
Title
Plasmon-enhanced stimulated Raman scattering microscopy with single-molecule detection sensitivity
Published Date
Nov 21, 2019
Journal
Volume
10
Issue
1
Pages
5318 - 5318
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