Effects of Glutathione and Histidine on NO Release from a Dimeric Dinitrosyl Iron Complex (DNIC)

Rates of NO release from synthetic dinitrosyl iron complexes (DNICs) are shown to be responsive to coordination environments about iron. The effect of biologically relevant cellular components, glutathione and histidine, on the rate of NO release from a dimeric, “Roussin’s Red Ester”, DNIC with bridging μ-S thioglucose ligands, SGlucRRE or [(μ-SGluc)Fe(NO)2]2 (SGluc = 1-thio-β-d-glucose tetraacetate), was investigated. From the Griess assay and...