Preferential Protein Partitioning in Biological Membrane with Coexisting Liquid Ordered and Liquid Disordered Phase Behavior: Underlying Design Principles

Several studies now show that certain proteins exhibit selective preference toward liquid ordered (L $_o ) or toward liquid disordered (L _d ) regions of the heterogeneous membrane and some of them have preference for the L _o -L _d interface. Spatially heterogenous organization of lipids, enriched in specific protein molecules, function as platforms for signaling and are involved in several other physiologically critical...