Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2

Volume: 6, Issue: 12
Published: Jun 22, 2021
Abstract
Mice are normally unaffected by SARS coronavirus 2 (SARS-CoV-2) infection since the virus does not bind effectively to the murine version of the angiotensin-converting enzyme 2 (ACE2) receptor molecule. Here, we report that induced mild pulmonary morbidities rendered SARS-CoV-2–refractive CD-1 mice susceptible to this virus. Specifically, SARS-CoV-2 infection after application of low doses of the acute lung injury stimulants bleomycin or ricin...
Paper Details
Title
Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2
Published Date
Jun 22, 2021
Volume
6
Issue
12
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