Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence.

Published on Jan 1, 2021in Biomedicine & Pharmacotherapy4.545
· DOI :10.1016/J.BIOPHA.2020.110984
Xinmei Xu3
Estimated H-index: 3
(CDUTCM: Chengdu University of Traditional Chinese Medicine),
Huan Yi2
Estimated H-index: 2
(CDUTCM: Chengdu University of Traditional Chinese Medicine)
+ 7 AuthorsGang Fan9
Estimated H-index: 9
(CDUTCM: Chengdu University of Traditional Chinese Medicine)
Sources
Abstract
The increased incidence of metabolic diseases (e.g., diabetes and obesity) has seriously affected human health and life safety worldwide. It is of great significance to find effective drugs from natural compounds to treat metabolic diseases. Berberine (BBR), an important quaternary benzylisoquinoline alkaloid, exists in many traditional medicinal plants. In recent years, BBR has received widespread attention due to its good potential in the treatment of metabolic diseases. In order to promote the basic research and clinical application of BBR, this review provides a timely and comprehensive summary of the pharmacological and clinical advances of BBR in the treatment of five metabolic diseases, including type 2 diabetes mellitus, obesity, non-alcoholic fatty liver disease, hyperlipidemia, and gout. Both animal and clinical studies have proved that BBR has good therapeutic effects on these five metabolic diseases. The therapeutic effects of BBR are based on regulating various metabolic aspects and pathophysiological procedures. For example, it can promote insulin secretion, improve insulin resistance, inhibit lipogenesis, alleviate adipose tissue fibrosis, reduce hepatic steatosis, and improve gut microbiota disorders. Collectively, BBR may be a good and promising drug candidate for the treatment of metabolic diseases. More studies, especially clinical trials, are needed to further confirm its molecular mechanisms and targets. In addition, large-scale, long-term and multi-center clinical trials are necessary to evaluate the efficacy and safety of BBR in the treatment of these metabolic diseases.
References172
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#1Jasvinder A. Singh (UAB: University of Alabama at Birmingham)H-Index: 116
#2Angelo L. Gaffo (UAB: University of Alabama at Birmingham)H-Index: 21
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#1Milad Ashrafizadeh (University of Tabriz)H-Index: 18
#2Hojjat Samareh Fekri (KMU: Kerman Medical University)H-Index: 3
Last. Saeed SamarghandianH-Index: 1
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Since the beginning of the 21st century, studies have focused on developing drugs from naturally occurring compounds. Berberine (Brb) as a plant-derived compound is of interest. It is an isoquinone alkaloid which is derived from Berberis aristata, Berberis aquifolium and Berberis vulgaris. This plant-derived compound has a variety of pharmacological effects such as antioxidant, anti-inflammatory, antidiabetic, antidiarrheal, antitumor, antimicrobial, and anti-inflammatory. Various studies have d...
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#1Tong Xu (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 4
#2Tingting Kuang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 8
Last. Gang Fan (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 9
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Abstract Magnoflorine is an important quaternary aporphine alkaloid that is isolated from some commonly used herbal medicines (e.g., Sinomenium acutum (Thunb.) Rehder & E.H.Wilson and Coptis chinensis Franch.). In recent years, magnoflorine has received increasing attention due to its multiple pharmacological activities. This review provides the first comprehensive summary of the plant sources, pharmacological effects, toxicity, and pharmacokinetic characteristics of magnoflorine. The results in...
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#1Ying Zhong (Nanjing Medical University)H-Index: 3
#2Jing Jin (Nanjing University of Chinese Medicine)H-Index: 3
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Dysregulated glucagon drives hyperfunction in hepatic glucose output, which is the main cause of persistent hyperglycemia in type 2 diabetes. Berberine (Zhang et al., 2010) has been used as a hypoglycemic agent, yet the mechanism by which BBR inhibits hepatic gluconeogenesis remains incompletely understood. In this study, we treated diabetic mice with BBR, tested blood glucose levels, and then performed insulin, glucose lactate, and glucagon tolerance tests. Intracellular cAMP levels in hepatocy...
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#1Manoj Gurung (OSU: Oregon State University)H-Index: 4
#2Zhipeng Li (OSU: Oregon State University)H-Index: 1
Last. Natalia Shulzhenko (OSU: Oregon State University)H-Index: 21
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Abstract A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic review, we focused on the potential role of different bacterial taxa affecting diabetes. We have summarized evidence from 42 human studies reporting microbial associations with disease, and have identified supporting preclinical studies or clin...
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#1Jing Gong (HUST: Huazhong University of Science and Technology)H-Index: 10
#2Jingbin Li (HUST: Huazhong University of Science and Technology)H-Index: 6
Last. Fuer Lu (HUST: Huazhong University of Science and Technology)H-Index: 18
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Inflammation is recognized as the key pathological mechanism of type 2 diabetes. The hypoglyceamic effects of berberine (BBR) are related to the inhibition of the inflammatory response, but the mechanism is not completely clear. The inflammatory polarization of Raw264.7 cells and primary peritoneal macrophages were induced by LPS, and then effects and underlying mechanisms of BBR were explored. An inflammatory model was established by LPS treatment at different concentrations for different treat...
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#1George Sam Wang (Anschutz Medical Campus)H-Index: 15
#2Christopher Hoyte (Anschutz Medical Campus)H-Index: 10
In the 1920s, guanidine, the active component of Galega officinalis, was shown to lower glucose levels and used to synthesize several antidiabetic compounds. Metformin (1,1 dimethylbiguanide) is th...
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#1Wang Zhang (Guangzhou University of Chinese Medicine)H-Index: 1
#2Ji-Hao Xu (SYSU: Sun Yat-sen University)H-Index: 9
Last. Qi-Kui Chen (SYSU: Sun Yat-sen University)H-Index: 18
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Abstract Berberine and metformin, both established pharmaceutical agents with herbal origins, have incidental beneficial effects on multiple diseases, including diabetes. These effects have been speculated to occur via the gut microbiome. In this study, we administered either berberine or metformin to db/db mice and investigated changes in body weight, food intake, and blood glucose levels. Fresh stool samples were analyzed using 16 s rDNA high-throughput sequencing to evaluate the gut microbiom...
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#1Can Wang (Peking Union Medical College)H-Index: 4
#2Yan Wang (Peking Union Medical College)H-Index: 15
Last. Jian-Dong Jiang (Peking Union Medical College)H-Index: 52
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This study is designed to investigate the effects of berberine (BBR) on galectin-3 (Gal-3) and the relationships to its suppressive activities on adipocyte differentiation, proliferation and adiposity. Our results showed that BBR greatly suppressed the differentiation and proliferation of mouse primary preadipocytes isolated from epididymal white adipose tissue (eWAT), during which the expression level of Gal-3 was down-regulated significantly. Overexpression of Gal-3 totally abolished the suppr...
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#1Xiaopeng Zhu (Fudan University)H-Index: 5
#2Hua Bian (Fudan University)H-Index: 16
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Abstract Background Berberine (BBR), a natural compound extracted from Chinese herb, has been shown to effectively attenuate nonalcoholic fatty liver disease (NAFLD) in clinic. However, the mechanism underlying the effect of BBR is not fully understood. Stearyl-coenzyme A desaturase 1 (SCD1) mediates lipid metabolism in liver. Therefore, we hypothesized that SCD1 mediated the beneficial effect of BBR on NAFLD. Methods The expression of SCD1 was measured in the liver of NAFLD patients and ob/ob m...
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Cited By8
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#1Yunfeng Han (CDUTCM: Chengdu University of Traditional Chinese Medicine)
#2Yunan Xiang (CDUTCM: Chengdu University of Traditional Chinese Medicine)
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Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients. Based on the recent study results of BBR in diabetes treatment, the B...
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#1Rui Li (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 3
#2Xiaopeng Ai (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 7
Last. Xiaobo Wang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 7
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ABSTRCT Ethnopharmacological relevance Berberis dictyophylla F., a famous Tibetan medicine, has been used to prevent and treat diabetic retinopathy (DR) for thousands of years in clinic. However, its underlying mechanisms remain unclear. Aim of the study The present study was designed to probe the synergistic protection and involved mechanisms of berberine, magnoflorine and berbamine from Berberis dictyophylla F. on the spontaneous retinal damage of db/db mice. Materials and methods The 14-week ...
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#1Yi ChenH-Index: 4
#2Zhaohui JiangH-Index: 1
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Background null The combination of berberine (BER) and curcumin (CUR) has been verified with ameliorative effects on non-alcohol fatty liver disease (NAFLD). However, discrepant bioavailability and biodistribution of BER and CUR remained an obstacle to achieve synergistic effects. Multilayer nanovesicles have great potential for the protection and oral delivery of drug combinations. Therein lies bile salts inserted liposomes, named as bilosomes, that possesses long residence time in the gastroin...
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Abstract Berberine is a quaternary ammonium salt and naturally occurring benzylisoquinoline alkaloid, present in numerous medicinal herbs’ roots and stem bark as an active constituent, especially in the genus Berberis. It contains many pharmacological properties such as antioxidant, antiviral, antidiabetic, antidepressant, antidiarrheal, antibacterial any many more. Since nature is the best healer, it has been traditionally used in Ayurvedic and Chinese medicine to mitigate several disease condi...
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#2Ying Zhao (Beijing University of Chinese Medicine)H-Index: 2
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Abstract null null Introduction null Gut microbiota has been implicated in the pharmacological activities of many natural products. As an effective hypolipidemic agent, berberine (BBR)’s clinical application is greatly impeded by the obvious inter-individual response variation. To date, little evidence exists on the causality between gut microbes and its therapeutic effects, and the linkage of bacteria alterations to the inter-individual response variation. null null null Objectives null This st...
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#1Tong Xu (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 4
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Abstract Background The stem bark of Berberis kansuensis Schneid (BK) is a commonly used Tibetan medicine for the treatment of type 2 diabetes (T2D). However, its therapeutic mechanisms remain unclear. Aim of the study Our aim is to clarify the role of gut microbiota in the anti-diabetic activity of BK extract. Materials and methods High fat diet combined with low-dose streptozotocin (45 mg/kg) was used to establish a T2D rat model, and the body weight of rats was measured every five days. Fasti...
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The concerning worldwide increase of obesity and chronic metabolic diseases, such as T2D, dyslipidemia, and cardiovascular disease, motivates further investigations into preventive and alternative therapeutic approaches. Over the past decade, there has been growing evidence that the formation and activation of thermogenic adipocytes (brown and beige) may serve as therapy to treat obesity and its associated diseases owing to its capacity to increase energy expenditure and to modulate circulating ...
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Type 2 diabetes (T2D) is a worldwide health problem, ranked as one of the leading causes for severe morbidity and premature mortality in modern society. Management of blood glucose is of major importance in order to limit the severe outcomes of the disease. However, despite the impressive success in the development of new antidiabetic drugs, almost no progress has been achieved with regard to the development of novel insulin-sensitizing agents. As insulin resistance is the most eminent factor in...
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