Genomics of hypertension: the road to precision medicine

The known genetic architecture of blood pressure now comprises >30 genes, with rare variants resulting in monogenic forms of hypertension or hypotension and >1,477 common single-nucleotide polymorphisms (SNPs) being associated with the blood pressure phenotype. Monogenic blood pressure syndromes predominantly involve the renin–angiotensin–aldosterone system and the adrenal glucocorticoid pathway, with a smaller fraction caused by neuroendocrine...