The effect of alcohols as vehicles on the percutaneous absorption and skin retention of ibuprofen modified with l -valine alkyl esters
Abstract
The effect of various alcohols as vehicles on skin permeability was compared for unmodified ibuprofen (IBU) and ion pairs of ibuprofen with l-valine alkyl esters [ValOR][IBU], in which the alkyl chain R was changed from C1 to C8. In vitro permeation experiments were conducted in a Franz cell with porcine skin. Methanol, ethanol, and isopropanol solutions of 70% (v/v) were chosen as vehicles for penetrants and a buffer solution of pH 5.4 or 7.4...
Paper Details
Title
The effect of alcohols as vehicles on the percutaneous absorption and skin retention of ibuprofen modified with l -valine alkyl esters
Published Date
Jan 1, 2020
Journal
Volume
10
Issue
68
Pages
41727 - 41740
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