Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice
Abstract
We previously demonstrated that magnesium ions (Mg2+) was a novel therapeutic alternative for osteoarthritis (OA) through promoting the hypoxia inducible factor-1α (HIF-1α)-mediated cartilage matrix synthesis. However, oxidative stress can inhibit the expression of HIF-1α, amplify the inflammation that potentially impairs the therapeutic efficacy of Mg2+ in OA. Vitamin (VC), a potent antioxidant, may enhance the efficacy of Mg2+ in OA treatment....
Paper Details
Title
Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice
Published Date
May 1, 2021
Journal
Volume
6
Issue
5
Pages
1341 - 1352
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Notes
History