High Throughput Screening with SAMDI Mass Spectrometry for Directed Evolution

Volume: 142, Issue: 47, Pages: 19804 - 19808
Published: Nov 11, 2020
Abstract
Advances in directed evolution have led to an exploration of new and important chemical transformations; however, many of these efforts still rely on the use of low-throughput chromatography-based screening methods. We present a high-throughput strategy for screening libraries of enzyme variants for improved activity. Unpurified reaction products are immobilized to a self-assembled monolayer and analyzed by mass spectrometry, allowing for direct...
Paper Details
Title
High Throughput Screening with SAMDI Mass Spectrometry for Directed Evolution
Published Date
Nov 11, 2020
Volume
142
Issue
47
Pages
19804 - 19808
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