Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer’s disease spectrum
Abstract
Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer’s disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes. Participants included healthy controls, and subjects with...
Paper Details
Title
Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer’s disease spectrum
Published Date
Jan 1, 2020
Journal
Volume
28
Pages
102495 - 102495
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