Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjögren’s syndrome

Objective Altered homeostasis of salivary gland (SG) epithelial cells in Sjögren’s syndrome (SS) could be the initiating factor that leads to inflammation, secretory dysfunction and autoimmunity. Autophagy is an important homeostatic mechanism, whose deficiency is associated with inflammation and accumulation of Janus kinase (JAK)–signal transducer and activator of transcription (STAT) components. We aimed to evaluate whether autophagy is...