Increase in neuropeptide Y activity impairs social behaviour in association with glutamatergic dysregulation in diabetic mice

Patients with diabetes mellitus are reported to show a raised prevalence of mental disorders, which may be reflected in impaired social interaction. However, the mechanisms underlying such impairment in diabetes are unknown.The present study investigated whether social interaction is impaired in diabetic mice and whether central neuropeptide Y (NPY) and glutamatergic function are involved in such impairment.In the three-chamber test, social...