Icariin ameliorates estrogen-deficiency induced bone loss by enhancing IGF-I signaling via its crosstalk with non-genomic ERα signaling

Published on Feb 1, 2021in Phytomedicine4.268
· DOI :10.1016/J.PHYMED.2020.153413
Liping Zhou5
Estimated H-index: 5
(PolyU: Hong Kong Polytechnic University),
Christina Chui-Wa Poon1
Estimated H-index: 1
(PolyU: Hong Kong Polytechnic University)
+ 4 AuthorsMan Sau Wong35
Estimated H-index: 35
(PolyU: Hong Kong Polytechnic University)
#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Ka-Ying Wong (PolyU: Hong Kong Polytechnic University)H-Index: 2
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 8 authors...
Danggui Buxue Tang (DBT), a traditional Chinese Medicine decoction containing Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), is commonly prescribed for women in China as a remedy for menopausal symptoms. Previous study indicated that DBT stimulated cell growth and differentiation of human osteosarcoma MG-63 cells and exhibited estrogenic properties via estrogen receptors (ERs). The present study aimed to study the bone protective effects of DBT and its potential interactions with Selec...
8 CitationsSource
#1Zhenming Wang (JNU: Jinan University)H-Index: 3
#2Dongfang Wang (JNU: Jinan University)H-Index: 23
Last. Songlin Peng (JNU: Jinan University)H-Index: 6
view all 6 authors...
Osteoporosis is a bone disease characterized by reduced bone mass, which leads to increased risk of bone fractures, and poses a significant risk to public health, especially in the elderly population. The traditional Chinese medicinal herb Epimedii has been utilized for centuries to treat bone fracture and bone loss. Icariin is a prenylated flavonol glycoside isolated from Epimedium herb, and has been shown to be the main bioactive component. This review provides a comprehensive survey of previo...
45 CitationsSource
#1Ming-Xian Ho (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Christina Chui-Wa Poon (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 5 authors...
Genistein and icariin are flavonoid compounds that exhibit estrogen-like properties in inducing bone formation and reducing bone loss associated with estrogen deficiency in both preclinical and clinical studies. However, the mechanisms that are involved in mediating their estrogenic actions in bone cells are far from clear. The present study aimed to study the signaling pathways that mediate the estrogenic actions of genistein and icariin in osteoblastic cells. The effects of genistein and icari...
11 CitationsSource
: Osteoporosis is a significant public health problem, and a major cause of the disease is estrogen deficiency following menopause in women. In addition, considerable evidence now shows that estrogen is also a major regulator of bone metabolism in men. Since the original description of the effects of estrogen deficiency on bone by Fuller Albright more than 70 years ago, there has been enormous progress in understanding the mechanisms of estrogen and testosterone action on bone using human and mo...
45 CitationsSource
#1Faming TianH-Index: 2
#2Yongmei Wang (UCSF: University of California, San Francisco)H-Index: 19
Last. Daniel D. Bikle (UCSF: University of California, San Francisco)H-Index: 78
view all 3 authors...
Mechanical loading preserves bone mass and stimulates bone formation, whereas skeletal unloading leads to bone loss. In addition to osteocytes, which are considered the primary sensor of mechanical load, osteoblasts, and bone specific mesenchymal stem cells also are involved. The skeletal response to mechanical signals is a complex process regulated by multiple signaling pathways including that of insulin-like growth factor-1 (IGF-1). Conditional osteocyte deletion of IGF-1 ablates the osteogeni...
19 CitationsSource
#1Karin A. Jansen (Wellcome Trust Centre for Cell-Matrix Research)H-Index: 7
#1Karin Jansen (Wellcome Trust Centre for Cell-Matrix Research)H-Index: 1
Last. Christoph Ballestrem (Wellcome Trust Centre for Cell-Matrix Research)H-Index: 34
view all 3 authors...
Abstract The ability of cells to sense and respond to mechanical signals is vital in development and healthy tissue functioning. Many diseases are related to either changing mechanical properties of the tissue, or changes in the ability of cells to sense mechanical signals. This sensing occurs, in part, at integrin-associated complexes (IACs) that form sites of attachment between the cell and the extracellular matrix (ECM). In this review, we discuss the complex mechanical signals of the ECM. We...
96 CitationsSource
#1Zhidi Wu (JNU: Jinan University)H-Index: 4
#2Ling Ou (JNU: Jinan University)H-Index: 4
Last. Xiaofeng Zhu (JNU: Jinan University)H-Index: 8
view all 10 authors...
Abstract Icaritin (ICT), a hydrolytic product of icariin from the genus Epimedium, has many indicated pharmacological and biological activities. Several studies have shown that ICT has potential osteoprotective effects, including stimulation of osteoblast differentiation and inhibition of osteoclast differentiation. However, the molecular mechanism for this anabolic action of ICT remains largely unknown. Here, we found that ICT could enhance MC3T3-E1 subclone 14 preosteoblastic cell differentiat...
23 CitationsSource
#1Jean-François Arnal (University of Toulouse)H-Index: 51
#2Françoise Lenfant (University of Toulouse)H-Index: 35
Last. John A. Katzenellenbogen (University of Toulouse)H-Index: 87
view all 11 authors...
Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a key role in reproduction and exerting functions in numerous nonreproductive tissues. In this review, we attemp...
118 CitationsSource
#1Ching-Yun Chen (NTU: National Taiwan University)H-Index: 8
#2Kuo-Yun Tseng (NHRI: National Health Research Institutes)H-Index: 1
Last. Shankung Lin (NHRI: National Health Research Institutes)H-Index: 2
view all 6 authors...
: Many studies have indicated that loss of the osteoblastogenic potential in bone marrow mesenchymal stem cells (bmMSCs) is the major component in the etiology of the aging-related bone deficit. But how the bmMSCs lose osteogenic capability in aging is unclear. Using 2-dimentional cultures, we examined the dose response of human bmMSCs, isolated from adult and aged donors, to exogenous insulin-like growth factor 1 (IGF-1), a growth factor regulating bone formation. The data showed that the mitog...
15 CitationsSource
#1D.M.L. Cooper (U of S: University of Saskatchewan)H-Index: 25
#2C. E. Kawalilak (U of S: University of Saskatchewan)H-Index: 8
Last. James D. Johnston (U of S: University of Saskatchewan)H-Index: 16
view all 5 authors...
There is growing recognition of the role of micro-architecture in osteoporotic bone loss and fragility. This trend has been driven by advances in imaging technology, which have enabled a transition from measures of mass to micro-architecture. Imaging trabecular bone has been a key research focus, but advances in resolution have also enabled the detection of cortical bone micro-architecture, particularly the network of vascular canals, commonly referred to as ‘cortical porosity.’ This review aims...
48 CitationsSource
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