LncRNA MEG3 regulates microglial polarization through KLF4 to affect cerebral ischemia-reperfusion injury

Volume: 129, Issue: 6, Pages: 1460 - 1467
Published: Dec 1, 2020
Abstract
This study aimed to explore whether long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) affects the polarization of microglia in cerebral ischemia-reperfusion (I/R) injury through regulating Krüppel-like factor 4 (KLF4). A middle cerebral artery occlusion/reperfusion-induced (MCAO/R-induced) mouse model was established as an in vivo model. Oxygen and glucose confinement/reoxygenation-induced (OGD/R-induced) microglia (BV2 cells) were...
Paper Details
Title
LncRNA MEG3 regulates microglial polarization through KLF4 to affect cerebral ischemia-reperfusion injury
Published Date
Dec 1, 2020
Volume
129
Issue
6
Pages
1460 - 1467
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