Total-Body PET Imaging of Musculoskeletal Disorders.

Published on Jan 1, 2021in Pet Clinics
· DOI :10.1016/J.CPET.2020.09.012
Abhijit J. Chaudhari18
Estimated H-index: 18
(UC Davis: University of California, Davis),
William Raynor10
Estimated H-index: 10
(Drexel University)
+ 3 AuthorsAbass Alavi133
Estimated H-index: 133
(UPenn: University of Pennsylvania)
Imaging of musculoskeletal disorders, including arthritis, infection, osteoporosis, sarcopenia, and malignancies, is often limited when using conventional modalities such as radiography, computed tomography (CT), and MR imaging. As a result of recent advances in Positron Emission Tomography (PET) instrumentation, total-body PET/CT offers a longer axial field-of-view, higher geometric sensitivity, and higher spatial resolution compared with standard PET systems. This article discusses the potential applications of total-body PET/CT imaging in the assessment of musculoskeletal disorders.
#8Thomas Werner (HUP: Hospital of the University of Pennsylvania)H-Index: 20
OBJECTIVES The aim of this study was to quantify subchondral bone remodeling in the elbows, hands, knees, and feet using volumetric and metabolic parameters derived from 18F-sodium fluoride positron emission tomography (NaF-PET) and to assess the convergent validity of these parameters as an index of joint degeneration and preclinical osteoarthritis. METHODS A retrospective analysis was conducted in 34 subjects (32 males, 2 females) with metastatic bone disease who underwent full-body NaF-PET/CT...
#1Mark X. Cleary (Johns Hopkins University)H-Index: 1
#2Laura M. Fayad (Johns Hopkins University)H-Index: 37
Last. Shivani Ahlawat (Johns Hopkins University)H-Index: 18
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PURPOSE To evaluate the prevalence, imaging appearance, and significance of popliteal lymph nodes (PLN) on magnetic resonance imaging (MRI) in patients with distal femoral or proximal tibial osteosarcoma (OS). METHOD AND MATERIALS This study included consecutive patients with OS presenting from May 2016 to March 2018. Inclusion criteria were patients with distal femoral or proximal tibial OS with MRI and pathology at our institution. On MRI, two radiologists recorded primary tumor features (size...
#1Chenyang Zhao (Peking Union Medical College Hospital)H-Index: 7
#2Rui Zhang (Peking Union Medical College Hospital)H-Index: 3
Last. Yuxin Jiang (Peking Union Medical College Hospital)H-Index: 22
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Abstract Owing to the heavy health burdens from rheumatoid arthritis, a sensitive and objective imaging method is needed for early diagnosis and accurate evaluation of the disease. We aimed to fabricate vascular epithelial growth factor (VEGF)–targeted microbubbles (MBs) to evaluate the expression levels of VEGF within the inflammatory lesions of rats with adjuvant-induced arthritis (AIA) using a multimodal photoacoustic (PA)/ultrasound (US) imaging system. Fluorescein isothiocyanate–biotin doub...
#1William F Wright (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
#2Paul G. Auwaerter (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 28
Fever has preoccupied physicians since the earliest days of clinical medicine. It has been the subject of scrutiny in recent decades. Historical convention has mostly determined that 37.0°C (98.6°F) should be regarded as normal body temperature, and more modern evidence suggests that fever is a complex physiological response involving the innate immune system and should not be characterized merely as a temperature above this threshold. Fever of unknown origin (FUO) was first defined in 1961 by P...
#1Maqsood YaqubH-Index: 20
#2Nicki J F Verweij (VUMC: Vanderbilt University Medical Center)H-Index: 2
Last. Conny J. van der Laken (VUMC: Vanderbilt University Medical Center)H-Index: 19
view all 6 authors...
Treatment for rheumatoid arthritis (RA) should be started as early as possible to prevent destruction of bone and cartilage in affected joints. A new diagnostic tool for both early diagnosis and therapy monitoring would be valuable to reduce permanent joint damage. Positron emission tomography (PET) imaging of macrophages is a previously demonstrated non-invasive means to visualize (sub)clinical arthritis in RA patients. We developed a kinetic model to quantify uptake of the macrophage tracer [1...
#1Sylvia S. Rhodes (UPenn: University of Pennsylvania)H-Index: 3
#2Alexandra S. Batzdorf (UPenn: University of Pennsylvania)H-Index: 5
Last. Chamith S. Rajapakse (UPenn: University of Pennsylvania)H-Index: 22
view all 11 authors...
BACKGROUND: Standard of care metabolic bone disease assessment relies on changes to bone quantity, which can only be detected after structural changes occur. PURPOSE: To investigate the usefulness of Bone Metabolism Score (BMS), derived from fluorine 18 labeled sodium fluoride ((18)F-NaF) PET/CT imaging as a biomarker of localized metabolic changes at the femoral neck. METHODS: In this retrospective study, 139 participants (68 females and 71 males, ages 21-75years) that had undergone (18)F-NaF P...
AIM: To compare the effects of high-dose therapy (HDT consisting of high-dose chemotherapy followed by autologous stem cell transplantation) and conventional-dose chemotherapy (non-HDT) on the uptake of (18)F-sodium fluoride (NaF) in the whole bone, pelvis, and femoral neck of multiple myeloma (MM) patients. METHOD: The data of 19 MM patients who received HDT (61.5 (SD 5.6) years) and 11 MM patients who received conventional-dose chemotherapy (70.9 (SD 7.2) years) were collected in a prospective...
#1Ting-Heng Chou (The Research Institute at Nationwide Children's Hospital)H-Index: 5
#2Mitchel R. Stacy (OSU: Ohio State University)H-Index: 12
Peripheral arterial disease (PAD) is an atherosclerotic occlusive disease of the non-coronary vessels that is characterized by lower extremity tissue ischemia, claudication, increased prevalence of lower extremity wounds and amputations, and impaired quality of life. Critical limb ischemia (CLI) represents the severe stage of PAD and is associated with additional risk for wound formation, amputation, and premature death. Standard clinical tools utilized for assessing PAD and CLI primarily focus ...
#1Søren Hess (University of Southern Denmark)H-Index: 19
Fever of unknown origin, bacteremia, and febrile neutropenia are diagnostic challenges. FDG-PET/CT is a well-established modality in infection imaging and the literature increasingly supports its use in these settings. In fever of unknown origin, FDG-PET/CT is helpful, but diagnostic yield depends on patient selection and inflammatory markers. In bacteremia, FDG-PET/CT is cost-effective, reduces morbidity and mortality, and impacts treatment strategy. Although use of FDG-PET/CT in these domains ...
#1Domenico Albano (University of Palermo)H-Index: 26
#2Carmelo Messina (University of Milan)H-Index: 22
Last. Luca Maria Sconfienza (University of Milan)H-Index: 42
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To date, sarcopenia is considered a patient-specific imaging biomarker able to predict clinical outcomes. Several imaging modalities, including dual-energy X-ray absorptiometry (DXA), computed tomography (CT), magnetic resonance (MR), and ultrasound (US), can be used to assess muscle mass and quality and to achieve the diagnosis of sarcopenia. With different extent, all these modalities can provide quantitative data, being thus reproducible and comparable over time. DXA is the one most commonly ...
Cited By1
#1Dario F Mazza (Stanford University)H-Index: 1
#2Robert D. BoutinH-Index: 32
Last. Abhijit J. ChaudhariH-Index: 18
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ABSTRACT This study systematically reviewed the published literature on the objective characterization of myofascial pain syndrome and myofascial trigger points using imaging methods. PubMed, Embase, Ovid and the Cochrane Library databases were utilized, while citation searching was conducted in Scopus. Citations were restricted to those published in English and in peer-reviewed journals between 2000-2021. Out of 1,762 abstracts screened, 69 articles underwent full-text review and 33 were includ...
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