Substrate Resistance to Traction Forces Controls Fibroblast Polarization
Abstract
The mechanics of fibronectin-rich extracellular matrix regulate cell physiology in a number of diseases, prompting efforts to elucidate cell mechanosensing mechanisms at the molecular and cellular scale. Here, the use of fibronectin-functionalized silicone elastomers that exhibit considerable frequency dependence in viscoelastic properties unveiled the presence of two cellular processes that respond discreetly to substrate mechanical properties....
Paper Details
Title
Substrate Resistance to Traction Forces Controls Fibroblast Polarization
Published Date
Dec 1, 2020
Journal
Volume
119
Issue
12
Pages
2558 - 2572
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Notes
History