Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets
Abstract
Conversion of tryptophan to N-formylkynurenine is the first and rate-limiting step of the tryptophan metabolic pathway (i.e., the kynurenine pathway). This conversion is catalyzed by three enzyme isoforms: indoleamine 2,3-dioxygenase 1 (IDO1), indoleamine 2,3-dioxygenase 2 (IDO2), and tryptophan 2,3-dioxygenase (TDO). As this pathway generates numerous metabolites that are involved in various pathological conditions, IDOs and TDO represent...
Paper Details
Title
Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets
Published Date
May 1, 2021
Journal
Volume
221
Pages
107746 - 107746
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