Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults
Abstract
Studies suggest that tau deposition starts in the anterolateral entorhinal cortex (EC) with normal aging, and that the presence of β-amyloid (Aβ) facilitates its spread to neocortex, which may reflect the beginning of Alzheimer's disease (AD). Functional connectivity between the anterolateral EC and the anterior-temporal (AT) memory network appears to drive higher tau deposition in AT than in the posterior-medial (PM) memory network. Here, we...
Paper Details
Title
Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults
Published Date
Nov 20, 2020
Journal
Volume
41
Issue
2
Pages
366 - 375
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