Melatonin ameliorates neuropathy in diabetic rats by abating mitochondrial dysfunction and metabolic derangements.

To investigate the impact of melatonin per se and in combination with gabapentin in a laboratory animal model of experimental diabetes and associated neuropathy in rats. Rats from all the groups except the vehicle control group received a single dose of streptozotocin 45 mg/kg, i.p. and fructose 10% through drinking water for 8 weeks and subsequently administered with melatonin (25 and 50 mg/kg, p.o.) per se or along with gabapentin (100 mg/kg,...