Review of silicone surface modification techniques and coatings for antibacterial/antimicrobial applications to improve breast implant surfaces.

Published on Feb 1, 2021in Acta Biomaterialia7.242
· DOI :10.1016/J.ACTBIO.2020.11.020
Mylan Lam2
Estimated H-index: 2
(ISPG: Institut Galilée),
Véronique Migonney25
Estimated H-index: 25
(ISPG: Institut Galilée),
Céline Falentin-Daudre1
Estimated H-index: 1
(ISPG: Institut Galilée)
Abstract Silicone implants are widely used in the medical field for plastic or reconstructive surgeries for the purpose of soft tissue issues. However, as with any implanted object, healthcare-associated infections are not completely avoidable. The material suffers from a lack of biocompatibility and is often subject to bacterial/microbial infections characterized by biofilm growth. Numerous strategies have been developed to either prevent, reduce, or fight bacterial adhesion by providing an antibacterial property. The present review summarizes the diverse approaches to deal with bacterial infections on silicone surfaces along with the different methods to activate/oxidize the surface before any surface modifications. It includes antibacterial coatings with antibiotics or nanoparticles, covalent attachment of active bacterial molecules like peptides or polymers. Regarding silicone surfaces, the activation step is essential to render the surface reactive for any further modifications using energy sources (plasma, UV, ozone) or chemicals (acid solutions, sol-gel strategies, chemical vapor deposition). Meanwhile, corresponding work on breast silicone prosthesis is discussed. The latter is currently in the line of sight for causing severe capsular contractures. Specifically, to that end, besides chemical modifications, the antibacterial effect can also be achieved by physical surface modifications by adjusting the surface roughness and topography for instance.
📖 Papers frequently viewed together
274 Citations
375 Citations
9 Authors (Hans J. Griesser, ..., Mawson Lakes)
#1Pablo Rougerie (UFRJ: Federal University of Rio de Janeiro)H-Index: 6
#2Laurent Pieuchot (CNRS: Centre national de la recherche scientifique)H-Index: 14
Last. Karine Anselme (CNRS: Centre national de la recherche scientifique)H-Index: 44
view all 8 authors...
How biophysical cues can control tissue morphogenesis is a central question in biology and for the development of efficient tissue engineering strategies. Recent data suggest that specific topographies such as grooves and ridges can trigger anisotropic tissue growth. However, the specific contribution of biologically relevant topographical features such as cell-scale curvature is still unclear. Here we engineer a series of grooves and ridges model topographies exhibiting specific curvature at th...
4 CitationsSource
#1Jiyeon Ham (UPR-RP: UPRRP College of Natural Sciences)H-Index: 4
#2Young-Min Kim (SNU: Seoul National University)H-Index: 59
Last. Yan Lee (UPR-RP: UPRRP College of Natural Sciences)H-Index: 28
view all 15 authors...
The surface of human silicone breast implants is covalently grafted at a high density with a 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer. Addition of cross-linkers is essential for...
3 CitationsSource
#1Peter G. Cordeiro (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 52
#2Paola Ghione (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 12
Last. Steven M. Horwitz (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 65
view all 8 authors...
ABSTRACT Background : The risk of BIA-ALCL for patients with textured breast implants has been estimated between 1/2832 and 1/30,000 women. Existing studies estimating the numbers exposed and at risk, may have under reported cases, and/or lacked comprehensive follow-up. Our objective is to determine the risk of BIA-ALCL in a defined cohort of patients reconstructed with macro-textured breast implants and consistently followed long-term. Methods : A prospective cohort study was conducted in patie...
45 CitationsSource
#1Mylan Lam (ISPG: Institut Galilée)H-Index: 2
#2Vivien Moris (ISPG: Institut Galilée)H-Index: 1
Last. Céline Falentin-Daudré (ISPG: Institut Galilée)H-Index: 9
view all 5 authors...
Abstract Silicone-based materials are largely used in plenty of fields, especially in the biomedical field as implantable devices for surgery purposes. However, due to recent issues, the safety of the material has been reconsidered. In this work, we aim to graft a bioactive polymer on silicone breast implants shell surface to allow better integration of the implant inside the body and also a decrease of the bacterial adhesion. To functionalize silicone material, we develop a simple method to fir...
3 CitationsSource
#1Safa Manav (Gazi University)H-Index: 1
#2M. Sühan Ayhan (Gazi University)H-Index: 1
Last. Erdem Sahin (Gazi University)
view all 7 authors...
SUMMARY Background Capsular contracture remains a problem following breast implant surgery. Although impact of biofilm and implant surface on capsule formation have been demonstrated, interaction of microorganisms with different surface types has not been clarified yet. We aimed to compare the ability of biofilm formation of implants with different surfaces, under standard conditions and to demonstrate its impact on capsular contracture. Methods Twenty-four rats were divided into four groups. Mi...
3 CitationsSource
#1Sunah Kang (UPR-RP: UPRRP College of Natural Sciences)H-Index: 7
#2Jungah Kim (UPR-RP: UPRRP College of Natural Sciences)H-Index: 2
Last. Yan LeeH-Index: 28
view all 14 authors...
Implants based on silicone elastomers, polydimethylsiloxane (PDMS), have been widely used for breast augmentation and reconstruction, but excessive foreign body reactions around implants often cause serious side effects such as capsular contracture. In our previous study, we covalently grafted 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymers on the surface of PDMS blocks by UV-induced polymerization and showed effective reduction of capsular formation around the MPC-grafted PDMS in ...
7 CitationsSource
#2Ruth Graf (UFPR: Federal University of Paraná)H-Index: 17
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon T-cell, CD-30+/ALK lymphoma. Late (9 years) periprosthetic fluid (seroma) is the most common presentation (90% of the cases). A combination of textured breast implant, bacterial contamination, and genetic predisposition seems to be necessary for BIA-ALCL to occur. There are 35 million patients with implants in the world, and at the present moment, 573 cases of BIA-ALCL have been reported. The risk of developing BI...
23 CitationsSource
#2Vincent Humblot (University of Paris)H-Index: 28
#3Emile Jubeli (University of Paris-Sud)H-Index: 12
Last. Céline Falentin-Daudré (ISPG: Institut Galilée)H-Index: 9
view all 7 authors...
The purpose of this study is to present the poly(caprolactone) (PCL) functionalization by the covalent grafting of poly(sodium styrene sulfonate) on electrospun scaffolds using the “grafting from” technique and evaluate the effect of the coating and surface wettability on the biological response. The “grafting from” technique required energy (thermal or UV) to induce the decomposition of the PCL (hydro)peroxides and generate radicals able to initiate the polymerization of NaSS. In addition, UV i...
13 CitationsSource
#1Tamilselvan Mohan (University of Maribor)H-Index: 19
#2Alja Čas (University of Maribor)H-Index: 1
Last. Janez RebolH-Index: 2
view all 8 authors...
Engineering functional biomaterials surfaces that resist biofilm formation triggered by unspecific protein adsorption is a key challenge, and these biosurfaces hold a huge potential in implant-associated infection. Herein, we report a water-based facile approach to install carboxylated-hyaluronic acid and sulfated-fucoidan on cationically tethered polydimethylsiloxane (PDMS) implant. We showed that these hydrophilic, charged, polysaccharide-based biosurfaces/biocoatings provide long-term stabili...
14 CitationsSource
#1Julie Martin (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Jean Martinez (CNRS: Centre national de la recherche scientifique)H-Index: 67
Last. Gilles Subra (CNRS: Centre national de la recherche scientifique)H-Index: 16
view all 4 authors...
As bioinert material, silicone has to be modified to display suitable biological properties. Peptides are attractive additives for such a purpose. Most of the time, several steps are needed for the synthesis of the peptide-modified silicone: first the silicone surface is modified to display a reactive function, then a bifunctional spacer can be grafted, and finally, the peptide is attached on the reactive group. However, some other alternatives exist to reduce the number of steps, involving eith...
6 CitationsSource
Cited By7
Abstract null null The present work described the cold fabrication of a P-32 radioactive source to be used in CNS cancer using epoxy resin. The epoxy plaque fabricated with Teflon mold presented better agreement. MCNP simulation evaluated the radiation dose. Special attention was given to factors that can impact dose distribution. Average dose was 16.44 ± 2.89% cGy/s. Differences of less than 0.01 cm in thickness within the plaque lead to differences of up to 12% in the dose rate.
#1Wuwei Li (VCU: Virginia Commonwealth University)
#2Yuanhang Yang (VCU: Virginia Commonwealth University)
Last. Xuewei Wang (VCU: Virginia Commonwealth University)
view all 8 authors...
#1Wenlong Li (Ha Tai: Xiamen University)
#2Eng San Thian (NUS: National University of Singapore)H-Index: 29
Last. Lei Ren (Ha Tai: Xiamen University)H-Index: 32
view all 5 authors...
Healthcare-acquired infections as well as increasing antimicrobial resistance have become an urgent global challenge, thus smart alternative solutions are needed to tackle bacterial infections. Antibacterial materials in biomedical applications and hospital hygiene have attracted great interest, in particular, the emergence of surface design strategies offer an effective alternative to antibiotics, thereby preventing the possible development of bacterial resistance. In this review, recent progre...
1 CitationsSource
Abstract null null In recent decades synthetic polymers have gained increasing popularity, and nowadays they are an integral part of people’s daily lives. In addition, owing to their competitive advantage and being susceptible to modification, polymers have stimulated the fast development of innovative technologies in many areas of science. Biopolymers are of particular interest in various branches of medicine, such as implantology of bones, cartilage and skin tissues as well as blood vessels. B...
3 CitationsSource
Abstract null null Poly(dimethylsiloxane) (PDMS) is known as one of the most established polymers for making elastomers. Therefore, it is commonly used for the fabrication of biomedical devices. Many PDMS surface modification processes have been proposed recently to increase PDMS reliability in medical fields. However, the modified surface's long-term stability is still limited. Hydrophobic recovery of PDMS is widely recognized as a factor that reduces the efficacy of PDMS surface modification. ...
#1Mina Zare (NUS: National University of Singapore)H-Index: 5
#2Erfan Rezvani Ghomi (NUS: National University of Singapore)H-Index: 9
Last. Seeram Ramakrishna (NUS: National University of Singapore)H-Index: 162
view all 4 authors...
Silicone is a synthetic polymer widely used in the biomedical industry as implantable devices since 1940, owing to its excellent mechanical properties and biocompatibility. Silicone biomaterials are renowned for their biocompatibility due to their inert nature and hydrophobic surface. A timeline illustration shows critical development periods of using silicone in varied biomedical applications. In this review, silicone properties are discussed along with several biomedical applications, includin...
#1Maria Nowacka (PAN: Polish Academy of Sciences)H-Index: 9
#2Anna Rygala (TUL: Lodz University of Technology)H-Index: 5
Last. Anna Bozena Kowalewska (PAN: Polish Academy of Sciences)H-Index: 85
view all 4 authors...
Intrinsic hydrophobicity is the reason for efficient bacterial settlement and biofilm growth on silicone materials. Those unwelcomed phenomena may play an important role in pathogen transmission. We have proposed an approach towards the development of new anti-biofilm strategies that resulted in novel antimicrobial hydrophobic silicones. Those functionalized polysiloxanes grafted with side 2-(carboxymethylthioethyl)-, 2-(n-propylamidomethylthioethyl)- and 2-(mercaptoethylamidomethylthioethyl)- g...
1 CitationsSource